A passenger plane has crashed in France, with all 148 people on board thought to have died.
The Airbus A320, operated by Lufthansa's Germanwings budget airline, came down in the southern French Alps between Barcelonnette and Digne.
It was en route from Barcelona to Dusseldorf.
France's President Francois Hollande said there was likely to be "no survivors".
The country's Prime Minister Manuel Valls said the causes of the crash were not yet known.
"We of course don't know the reasons for the crash," he told reporters.
"We obviously fear that the 142 to 150 passengers and crew died today, given the conditions of this crash."
France's interior ministry says debris from the airliner has been found near a village in the region.
A total of 142 passengers, two pilots and four cabin crew, were on board the plane.
Mr Valls said he had activated the ministerial crisis cell to help coordinate the aftermath of the crash. He added that he had sent Interior Minister Bernard Cazeneuve to the site of the incident.
Germanwings says it cannot confirm the reports. Airbus says it is "assessing" the situation.
Captain Mike Vivian, former Head of Flight Operations at the Civil Aviation Authority, told Sky News: "German Wings is a very competent company given it is owned by the main German flag-carrier and it flies basically short-haul routes.
"The Airbus A320 is a successful aeroplane and has been around for over 20 years.
"It surprises me, that this aircraft flying from Barcelona to Dusseldorf, would have been at low altitude because nobody goes low in the Alps unless you are landing at Zurich or Geneva.
"So something catastrophic as either taken place or there has been a major emergency. If it was the second it would probably have been preceded or consistent with a radio call.
"I know one or two of your viewers will be concerned because of the recent accident in the Far East, of which we don't know the circumstances. It tends to suggest weather was a factor.
"But the Airbus A320 and the family is a successful machine. They are operating all over the world and they are intrinsically a short-haul aircraft and have a very good safety record."
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