At least one person has died after dozens of vehicles were involved in a motorway pile-up on the M40, with "in excess of 30 people" being treated at the scene.
The crash occurred just before 7.50am this morning on the northbound carriageway between junctions 9 and 10 in Bicester, Oxfordshire.
That stretch of the motorway has been closed by the emergency services, and is not expected to open until 2.30pm. A couple of southbound lanes have now reopened.
"It is quite a major collision. I understand that there are about 30 vehicles involved," a spokeswoman for the South Central Ambulance Service said.
"We have a lot of resources on the scene - ambulances, our helicopter ambulance, rapid response vehicles, our doctor and our hazardous area response team."
According to the Met Office, it was "quite foggy" in the area this morning, and this would have hampered visibility on the roads considerably.
Traffic was already busier than usual on the M40 as families began their getaways for the half-term holidays.
Meanwhile, several people have been "seriously injured" after a coach and a car crashed on the M1 at about 6.45am.
Bedfordshire Police have confirmed that the northbound stretch between junctions 12 and 13 will likely be closed until 1.30pm at the earliest.
The closures could see significant numbers of West Ham fans miss the 12.45pm kick-off against West Brom in the Midlands. They have been advised to avoid both motorways altogether.
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