Teenager Stephen Sutton, who raised more than £3m for charity, has died after losing his cancer battle.
Writing on his Facebook page, his mother wrote: "My heart is bursting with pride but breaking with pain for my courageous, selfless, inspirational son who passed away peacefully in his sleep in the early hours of this morning, Wednesday 14th May.
"The ongoing support and outpouring of love for Stephen will help greatly at this difficult time, in the same way as it helped Stephen throughout his journey.
"We all know he will never be forgotten, his spirit will live on, in all that he achieved and shared with so many."
David Cameron visited Stephen and said he was "an inspiration" The sad news came after his family said the 19-year-old had become too sick to communicate as his condition deteriorated.
He was readmitted to hospital on Monday after having previously been discharged when it appeared he had made a "miraculous recovery" by coughing up a tumour.
At the time he revealed that he was suffering from breathlessness and said doctors thought there was something blocking his airway.
He wrote on Facebook: "The doctors think there may be something restricting my airway again, they're not sure exactly what yet though (tumour regrowth, infection, inflammation, are all potential reasons mentioned), but are currently discussing the possibilities and my scan results to decide what to do next."
Mr Sutton, from Burntwood in Staffordshire, was diagnosed with bowel cancer when he was 15.
Despite treatment the tumours spread, with doctors telling him the disease was terminal in 2012.
Hundreds of thousands of people have supported his fundraising efforts for the Teenage Cancer Trust since he posted a picture of himself in hospital in April with a goodbye message as he thought he was nearing death.
Among them was Prime Minister David Cameron.
The amount raised totals £3.24m to date.
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